<b>How long does ivermectin work in your system?</b> Ivermectin is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine. The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
<b>Can river blindness be cured?</b> This is something of a shock, because the textbook explanation of the disease is infection by filarial worms, Onchocerca volvulus, cured by annual treatment with ivermectin, a drug which kills the young microfilariae the adult worms produce in the body. Blindness follows when the microfilariae migrate to the eyes.
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